High Quality in stock 434-13-9 Lithocholic Acid good supplier CAS NO.434-13-9

High Quality in stock 434-13-9 Lithocholic Acid good supplier

Stone bile acid can kill glioma cells, harmless to normal nerve cells, the specific principle of action: low concentration of stone bile acid (LCA) can make BE (2)-m17 and SK-n-MCIXC cells sensitive to hydrogen peroxide-induced cell decay, a certain concentration of LCA makes the original culture of human neuronal cells have a certain resistance to this type of cell death. LCA can not only achieve the killing of BE(2)-m17 and SK-n-MCIXC cells by triggering the activation of mitochondrial transmissibly and the activation of the trigger CASPASE-9, but also through the external path of cell decay involving the activation of the trigger CASPASE-8. These intrinsic and external pathways of tumor cell decay can be interpreted using apoptosis cascading reactions.